I was carrying out an aldol reaction with 2'-hydroxyacphenone and 4-methythiobenzaldhye with KOH in methanol there was no reaction after beeing left over night . I then repeated the reaction at with heat and reflux and again no reaction. When i carried the reaction out with NaOH in ethanol with heat and reflux it had worked.
Is there any reason for the reaction not to work with KOH and methanol as the reagent ?
Temperature is also important. When reaction takes place at RT, the aldol addition product is produced. At 50C, the aldol condensation product is isolated..
