ACS Community for Combinatorial Science
Young Investigators Panel
Welcome to the ACS Combinatorial Science Young Investigators Panel site, highlighting some of the latest and most exciting advances in combinatorial chemistry, biology, materials science, and analysis. The Panel is a diverse group of advanced graduate student, postdoctoral, and professional scientists who are active researchers in various fields that use and develop combinatorial methods. They write here about research that excites, instructs, or inspires them, in consultation with members of the Journal's Editorial Advisory Board. Here you will also find an up-to-date calendar of meetings of interest to investigators in combinatorial science.
Panel members serve on a rotating basis. Nominations for new members, and comments or suggestions for the site, are gratefully accepted at email@example.com.
M.G. Finn, Editor-in-Chief
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors
Yollete V. Guillen Schlippe, Matthew C. T. Hartman, Kristopher Josephson, and Jack W. Szostak*
Howard Hughes Medical Institute, Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital
Journal of the American Chemical Society, 2012, 134(25), 10469-10477.
Highlight by: Ms. Zinaida Polonskaya, The Scripps Research Institute
Peptide-based drugs have the potential to combine the advantages of small molecule drugs (size, low production costs, ease of storage and handling) with those of biologics (high selectivity and specificity, low toxicity). Large peptide libraries (>106 members) can be screened using molecular evolution techniques, which facilitates lead identification. But until recently peptides have been considered relatively poor drug candidates due to their susceptibility to protease degradation and low bioavailability. While inclusion of unnatural amino acids and cyclization of the peptide backbone can increase both peptide stability and affinity, such modifications are not readily incorporated using standard ribosomal peptide synthesis. More...
Neural stem cell specific fluorescent chemical probe binding to FABP7
Seong-Wook Yun, Cheryl Leong, Duanting Zhai, Yee Ling Tan, Linda Lim, Xuezhi Bi, Jae-Jung Lee, Han Jo Kim, Nam-Young Kang, Shin Hui Ng, Lawrence W. Stanton, and Young-Tae Chang* National University of Singapore
Proceedings of the National Academy of Sciences of the United States of America , 2012, 134, 10795-10798.
Highlight by: Dr. Eunha Kim, Massachusetts General Hospital / Harvard Medical School
Molecular imaging is essential tool for current biomedical research fields. Therefore there is explosive increase on demands for the imaging tools and bio-probes for the visualization of cellular function and molecular process in living organism without perturbing their system. Chang and coworkers recently described a discovery of first Neural Stem Cell (NSC)-specific small molecular weight fluorescent chemical compound utilizing combinatorial concept, and they identified the binding target of the compound as intracellular NSC marker Fatty Acid Binding Protein 7 (FABP7) by proteomic analysis. This result clearly shows combinatorial science accelerating the discovery of new novel fluorescent bio-probes. More...
Combinatorial discovery of polymers resistant to bacterial attachment
Andrew L Hook, Chien-Yi Chang, Jing Yang, Jeni Luckett, Alan Cockayne, Steve Atkinson, Ying Mei, Roger Bayston, Derek J Irvine, Robert Langer, Daniel G Anderson, Paul Williams, Martyn C Davies, Morgan R Alexander* University of Nottingham, UK and Massachusetts Institute of Technology, USA
Nature Biotechnology, 2012, 134, 10795-10798.
Highlight by: Dr. Kaushik Chatterjee, Indian Institute of Science, Bangalore
This article reports the discovery of new polymeric materials that exhibit high resistance to bacterial attachment that could find use in infection-resistant coatings for medical devices. This group developed a high-throughput screening platform underpinned by a large library of co-polymers that is synthesized and printed as a microarray on an epoxy-coated glass slide using a robotic fluid handler. More...
Copper-Mediated Fluorination of Aryl Iodides
Patrick S. Fier and John F. Hartwig University of California
Journal of the American Chemical Society, 2012, 134, 10795-10798.
Highlight by: Jiang Wang, Shanghai Institute of Materia Medica
This report describes an operationally simple and high-yielding route to synthesize fluorine-substituted aromatic rings, providing access to molecules that could impact agrochemistry, medicinal chemistry, and other fields. Starting with iodine-substituted aryl rings, the researchers apply a combination of the copper complex ((tBuCN)2CuOTf) and AgF for the synthesize aryl fluoride. Sensitive functional groups, including esters, amides, aldehydes, ketones, and indole heterocycles are stable under the reaction conditions. More...
Fabrication of Two-Dimensional Gradient Layer-by-Layer Films for Combinatorial Biosurface Studies
Miloslav Sailer and Christopher J. Barrett* McGill University
Macromolecules , 2012, 134, 10795-10798.
Highlight by: Dr. Julie Albert, North Carolina State University
The authors describe a fabrication method for assembling gradient layer-by-layer (LbL) films from weak polyelectrolytes in which the assembly pH of the first component [poly(allylamine hydrochloride) (PAH)] is varied in one direction and the assembly pH of the second component [poly(acrylic acide) (PAA)] is varied orthogonally to the first. The resultant 2D combinatorial film provides access to thousands of assembly conditions on a single surface. More...
|In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors 1 month ago in ACS Combinatorial Science||by Laurie Smith|
|Neural stem cell specific fluorescent chemical probe binding to FABP7 2 years ago in ACS Combinatorial Science||by Laurie Smith|
|Fabrication of Two-Dimensional Gradient Layer-by-Layer Films for Combinatorial Biosurface Studies 2 years ago in ACS Combinatorial Science||by Laurie Smith|
|Copper-Mediated Fluorination of Aryl Iodides 2 years ago in ACS Combinatorial Science||by Laurie Smith|
|Combinatorial discovery of polymers resistant to bacterial attachment 2 years ago in ACS Combinatorial Science||by Laurie Smith|