ACS Community for Combinatorial Science
Young Investigators Panel
Welcome to the ACS Combinatorial Science Young Investigators Panel site, highlighting some of the latest and most exciting advances in combinatorial chemistry, biology, materials science, and analysis. The Panel is a diverse group of advanced graduate student, postdoctoral, and professional scientists who are active researchers in various fields that use and develop combinatorial methods. They write here about research that excites, instructs, or inspires them, in consultation with members of the Journal's Editorial Advisory Board. Here you will also find an up-to-date calendar of meetings of interest to investigators in combinatorial science.
Panel members serve on a rotating basis. Nominations for new members, and comments or suggestions for the site, are gratefully accepted at firstname.lastname@example.org.
M.G. Finn, Editor-in-Chief
High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials
Qin Wang, Xiaoxia Xia, Wenwen Huang, Yinan Lin, Qiaobing Xu,* and David L. Kaplan*
Department of Biomedical Engineering, Tufts University, Massachusetts, USA and State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
Advanced Functional Materials, 2014, in press, doi: 10.1002/adfm.201304106
Highlight by: Dr. Alessandro Poma, The Open University
This study describes for the first time the construction and screening of a Silk-Elastin-Like Protein (SELP) library in which different amino acids were tested at the “X” position of the elastin domain (thus obtaining a broader range of functional material properties) and systematically compared in terms of dynamic properties (thermal, electrochemical, mechanical and adhesive) using high-throughput methods. The aim of the authors was to improve the fundamental understanding of the stimuli-responsive properties of silk and elastin, together with the fulfillment of the need for more elastic polymeric systems in many biomaterial applications. More...
Screening Rhodium Metallopeptide Libraries “On Bead”: Asymmetric Cyclopropanation and a Solution to the Enantiomer Problem
Ramya Sambasivan and Zachary Ball*
Rice University Department of Chemistry
Angewandte Chemie, International Edition, 2012, 134(51), 8568-8572, doi: 10.1002/anie.201202512.
Highlight by: Dr. Thomas O. Painter, University of Kansas Center for Chemical Methodologies and Library Development
In this article, the authors confront the well known “enantiomer problem” that results when naturally occurring compounds are used for asymmetric induction, i.e. one product enantiomer is easily accessible, but the other is not. The article details a method for quickly generating libraries of peptide-based rhodium(II)-metallopeptides to identify catalysts of a cyclopropanation between simple alkenes and α-diazoesters. More...
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors
Yollete V. Guillen Schlippe, Matthew C. T. Hartman, Kristopher Josephson, and Jack W. Szostak*
Howard Hughes Medical Institute, Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital
Journal of the American Chemical Society, 2012, 134(25), 10469-10477.
Highlight by: Ms. Zinaida Polonskaya, The Scripps Research Institute
Peptide-based drugs have the potential to combine the advantages of small molecule drugs (size, low production costs, ease of storage and handling) with those of biologics (high selectivity and specificity, low toxicity). Large peptide libraries (>106 members) can be screened using molecular evolution techniques, which facilitates lead identification. But until recently peptides have been considered relatively poor drug candidates due to their susceptibility to protease degradation and low bioavailability. While inclusion of unnatural amino acids and cyclization of the peptide backbone can increase both peptide stability and affinity, such modifications are not readily incorporated using standard ribosomal peptide synthesis. More...
|High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials 3 years ago in ACS Combinatorial Science||by Laurie Smith|
|Screening Rhodium Metallopeptide Libraries “On Bead”: Asymmetric Cyclopropanation and a Solution to the Enantiomer Problem 3 years ago in ACS Combinatorial Science||by Laurie Smith|
|In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors 3 years ago in ACS Combinatorial Science||by Laurie Smith|
|Neural stem cell specific fluorescent chemical probe binding to FABP7 5 years ago in ACS Combinatorial Science||by Laurie Smith|
|Fabrication of Two-Dimensional Gradient Layer-by-Layer Films for Combinatorial Biosurface Studies 5 years ago in ACS Combinatorial Science||by Laurie Smith|
|Copper-Mediated Fluorination of Aryl Iodides 5 years ago in ACS Combinatorial Science||by Laurie Smith|