• Chiral synthesis in modern chemistry

    Chiral synthesis (enantioselective synthesis, also called asymmetric synthesis) is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. It is a key process in mod...
    Alex Dean
    created by Alex Dean
  • What is the difference between primary metabolites and secondary metabolites?

    Depending on the origin and function, metabolites can be divided into two major categories; namely, Primary and Secondary metabolites.   Primary metabolites are microbial products produced continuously during the...
    Alex Dean
    created by Alex Dean
  • How is X-ray crystallography applied?

    X-ray crystallography based characterisation of samples currently have became the favoured method for both definitive sample identification and drug discovery process. A three dimensional structure could be obtained b...
    Alex Dean
    created by Alex Dean
  • What are mTOR inhibitors and any clinical implications?

    The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a protein that in humans is encoded by the MTOR gene. mTO...
    Alex Dean
    created by Alex Dean
  • What's the role of immune checkpoint inhibitors?

    Immune checkpoints are proteins in the immune system that either turn up a signal or turn down a signal. These proteins help keep immune responses in check and can keep T cells from killing cancer cells. When these pr...
    Alex Dean
    created by Alex Dean
  • Is ADC linker vital to the success of antibody drug conjugates?

    Definitely yes. The ADC linker is of the same, if not more, importance as it determines the final success of an ADC.   A qualified linker should meet a lot of requirements. First, a liker should be stable in ci...
    Alex Dean
    created by Alex Dean
  • What is the relationship between RAS Signaling Pathway and cancer?

    Cell growth, proliferation, differentiation and aging are tightly controlled by a complex network of signaling pathways. The RAS proteins and RAS signaling pathway play an essential role in normal cellular proliferati...
    Alex Dean
    created by Alex Dean
  • Parbendazole

    What are the synonyms of parbendazole and why do chemicals like this always have so many synonyms?
    Alex Dean
    last modified by Alex Dean
  • Application of superparamagnetic iron oxide particles

    Superparamagnetic iron oxide microbeads have broad applications in biomedicine, such as magnetic cell isolation and biomolecules purification, magnetic resonance imaging of diseased tissues, magnetic immunoassay, targ...
    Alex Dean
    last modified by Alex Dean
  • IDO inhibitors in cancer treatment

    IDO, also referred to indoleamine 2,3-dioxygenase, is an enzyme that plays a role in suppressing the immune system through catalyzing the oxidative cleavage of Tryptophan because T cells undergoing antigen-dependent a...
    Alex Dean
    created by Alex Dean
  • Impurities and drug development

    Profiling and controlling impurities level and their side pharmaceutical effects is crucial in both drug development and manufacturing process as they may affect the efficacy and safety of APIs, and then lead to failu...
    Alex Dean
    created by Alex Dean
  • What Does Fluorine Chemistry Service Do?

    Background: fluorine compounds have had a profound impact on the development of bioactive for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals prescribed or administered in the clin...
    Alex Dean
    last modified by Alex Dean
  • DNA-Encoded Library Technology and Drug Discovery

    DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type co...
    Alex Dean
    created by Alex Dean
  • Therapeutic Effects of HDAC Inhibitors

    HDAC inhibitors to treat cancer As previously mentioned, two HDAC inhibitors, vorinostat and depsipetide, have recently been approved by the FDA in 2006 and 2009, respectively. This marks the official recognition of H...
    Alex Dean
    created by Alex Dean
  • Functions of mTOR inhibitors

    The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a protein that in humans is encoded by the MTOR gene. mTO...
    Alex Dean
    created by Alex Dean
  • Fluorine compounds in drug development

    Organic fluorine compounds have had a profound impact on the development of bioactive for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals prescribed or administered in the clinic c...
    Alex Dean
    created by Alex Dean
  • Superparamagnetic Iron Oxide Particles

    A targeted drug delivery system is the need of the hour. Guiding magnetic iron oxide nanoparticles with the help of an external magnetic field to its target is the principle behind the development of superparamagnetic...
    Alex Dean
    created by Alex Dean
  • DNA-Encoded Library Technology

    DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type co...
    Alex Dean
    created by Alex Dean
  • Drug Potency and ADC Cytotoxin

    Several groups hypothesized that it may be necessary to construct ADCs with drugs of much higher molar potencies than conventional chemotherapeutics to achieve therapeutically effective levels of active drug within tu...
    Alex Dean
    created by Alex Dean
  • Functions of Isotope Labeling

    Isotopes are variants of a particular chemical element which differ in neutron number, although all isotopes of a given element have the same number of protons in each atom. Isotope Variation Analysis (detection of ad...
    Alex Dean
    created by Alex Dean