• Reasoning and Analysis of the Molecular rearrangem.pdf

    Chemical science
    Ruishi Fang
    last modified by Ruishi Fang
  • Guide to Understanding X-ray Crystallography

    X-ray Crystallography is a scientific method of determining the precise positions/arrangements of atoms in a crystal where beams of X-ray strikes a crystal and causes the beam of light to diffract into many specific d...
    Alex Dean
    created by Alex Dean
  • Maximising the potential of AKT inhibitors as anti-cancer treatments

    Akt, or protein kinase B (PKB), is a Ser/Thr protein kinase that phosphorylates a variety of protein substrates to regulate numerous cellular functions. Such as protein synthesis, metabolism, transcription, cellular p...
    Alex Dean
    created by Alex Dean
  • HSP90 inhibitors: current development and potential in cancer therapy

    In the last decade, the molecular chaperone HSP90 has emerged as an important target in cancer therapeutics and has subsequently become the focus of several drug discovery and development efforts. The first-in-class H...
    Alex Dean
    created by Alex Dean
  • Matrix metalloproteinases: What do they not do? New substrates being identified

    Numerous reports have shown that Matrix metalloproteinases(MMPs) are directly implicated in almost every biological process involving matrix remodeling throughout the mammalian life span, from embryo implantation to c...
    Cathy Miller
    created by Cathy Miller
  • Exendins and exendin analogs for diabetic therapy

    Exendins are glucagon-like peptide-1 (GLP-1) receptor agonists with a greater resistance to dipeptidyl peptidase-IV degradation, a longer half-life, and are more potent in vivo activity than native GLP-1. Since exendi...
    Cathy Miller
    created by Cathy Miller
  • MHC-peptide tetramers for the analysis of antigen-specific T cells

    The development of the fluorescently labeled tetrameric MHC-peptide complex has enabled the direct visualization, quantification and phenotypic characterization of antigen-specific T cells using flow cytometry and has...
    Cathy Miller
    created by Cathy Miller
  • CBOD QUESTION

    Did  three CBODs using dilutions of 50, 150, and 275mls.  Used 15 mls polyseed and added TCMP.  This on a final effluent. Dilution water was less than .20 depletion,  and GGA was good  Results...
    Phil Warren
    created by Phil Warren
  • Hydrogen 1s 2p 3d Electron Cloud Forming Principle.doc

    The principle of electron cloud formation
    Ruishi Fang
    last modified by Ruishi Fang
  • Advances in Bioconjugation

    Bioconjugation is the process of joining of biomolecules to other biomolecules, small molecules, and polymers by chemical or biological means to form a novel complex consisting of both molecules linked together. When ...
    Alex Dean
    created by Alex Dean
  • Benefits of Virtual Screening

    Benefits of Virtual Screening include:   In silico study in medicine takes advantage of computer simulations to predict the protein-ligand binding site, reducing real laboratory experiments and accelerating the d...
    Alex Dean
    created by Alex Dean
  • Pharmaceutical formulation

    Pharmaceutical formulation is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. Development of novel dosage forms such as capsules, table...
    Alex Dean
    created by Alex Dean
  • Chiral synthesis in modern chemistry

    Chiral synthesis (enantioselective synthesis, also called asymmetric synthesis) is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. It is a key process in mod...
    Alex Dean
    created by Alex Dean
  • What is the difference between primary metabolites and secondary metabolites?

    Depending on the origin and function, metabolites can be divided into two major categories; namely, Primary and Secondary metabolites.   Primary metabolites are microbial products produced continuously during the...
    Alex Dean
    created by Alex Dean
  • How is X-ray crystallography applied?

    X-ray crystallography based characterisation of samples currently have became the favoured method for both definitive sample identification and drug discovery process. A three dimensional structure could be obtained b...
    Alex Dean
    created by Alex Dean
  • What are mTOR inhibitors and any clinical implications?

    The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a protein that in humans is encoded by the MTOR gene. mTO...
    Alex Dean
    created by Alex Dean
  • What's the role of immune checkpoint inhibitors?

    Immune checkpoints are proteins in the immune system that either turn up a signal or turn down a signal. These proteins help keep immune responses in check and can keep T cells from killing cancer cells. When these pr...
    Alex Dean
    created by Alex Dean
  • Is ADC linker vital to the success of antibody drug conjugates?

    Definitely yes. The ADC linker is of the same, if not more, importance as it determines the final success of an ADC.   A qualified linker should meet a lot of requirements. First, a liker should be stable in ci...
    Alex Dean
    created by Alex Dean
  • What is the relationship between RAS Signaling Pathway and cancer?

    Cell growth, proliferation, differentiation and aging are tightly controlled by a complex network of signaling pathways. The RAS proteins and RAS signaling pathway play an essential role in normal cellular proliferati...
    Alex Dean
    created by Alex Dean
  • Parbendazole

    What are the synonyms of parbendazole and why do chemicals like this always have so many synonyms?
    Alex Dean
    last modified by Alex Dean