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Pharmaceutical Roundtable request help filling data gaps in their solvent selection guide.


The ACS GCI Pharmaceutical Roundtable Solvent Selection Guide is based on an evaluation of a number of endpoints including safety, health, and environmental properties.  In some cases, there were no publicly available data for some of these endpoints for certain solvents. The guide reflects ongoing evaluation of publicly available information. Table 1 illustrates the missing data points for the respective solvents.  To improve the quality of the Solvent Selection Guide, the Roundtable is seeking to fill these data gaps.  Anyone with data on these missing data points is asked to contact the ACS GCI Pharmaceutical Roundtable at gcipr@acs.org.  Thank you for your support!


Welcome new members!


Ajinomoto North America became a member of the ACS GCI Chemical Manufacturer’s Roundtable. 


Rochester Midland Corporation became a member of the ACS GCI Formulators’ Roundtable. 


New members and prospective members are welcome at any time throughout the year in any of the ACS GCI Roundtables.  If you or your company would like to learn more, please contact Julie Manley at j_manley@acs.org.  Upcoming Roundtable meetings and events are co-located with the 17th Annual Green Chemistry & Engineering Conference the week of June 17 in Bethesda, MD.


Recent publications:


Comparative Performance Evaluation and Systematic Screening of Solvents in a Range of Grignard Reactions, published online May 3, 2013 in Green Chemistry, is the result of a collaborative research grant from the ACS GCI Pharmaceutical Roundtable to Prof. Wei Zhang, University of Massachusetts-Boston.  The work summarizes the outcome of a systematic evaluation of the reaction efficiency, ease of subsequent work-up, safety and greenness of the solvent effect on the Grignard reaction of benzyl, aryl and heteroaromatic substrates. 


Sustainable Practices in Medicinal Chemistry: Current State and Future Directions published online April 15, 2013 in the ACS Journal of Medicinal Chemistry,  is a perspective on the current state of environmentally sustainable practices in medicinal chemistry.  The medicinal chemistry group of the ACS GCI Pharmaceutical Roundtable aimed to share best practices more widely as well as highlight future developments.


Green Chemistry Articles of Interest to the Pharmaceutical Industry, published online on March 20, 2013 in Organic Process Research & Development, highlights greener pharmaceutically relevant advances as reported in recent literature. 


 

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By Svetlana Dimovski

Manager Innovation and Science Relations, BASF NA

 

As the world’s leading chemical company, BASF is well positioned for outreach & development to work with world class innovators and companies across the United States as well as many other parts of the world, and learn more about their work and interests.

 

http://images.magnetmail.net/images/clients/ACS1/ACS/Membership/GreenChemistryInstitute/The_Nexus/May_2013/Customer_magazine_PUR_sm.jpgFor instance, the Footwear industry is very close to the everyday consumer where increasing demand for green and sustainable products is visible.  The Footwear industry is influenced by fashion and rapidly changing customer demand, requiring new solutions and materials.  BASF developed the PURE shoe concept, being the first all Polyurethane (PU) shoe, designed to demonstrate the enormous versatility of Polyurethanes in Footwear applications as well as innovation in chemistry.  The next-generation PURE 1.2 Balance demonstrates how alternative raw material sources such as renewables can be integrated into consumer goods, with the future potential to reduce consumption of non-renewable resources.  With this holistic concept BASF also proves its competence as a developer of customer-oriented and targeted solutions to meet the requirements of the shoe industry in the field of sustainability.

 

At BASF we create chemistry for a sustainable future;  therefore we look for sustainable innovations that address the biggest problems and long-term challenges related to resources, environment and climate, food and nutrition, and quality of life. As a chemical and materials science company together with our innovation partners we provide solutions for the Transportation, Construction, Consumer Goods, Health & Nutrition, Electronics, Agriculture and Energy & Resources industries.

 

Sustainability of our society, our resources and our planet, to a certain extent, is everyone's job. External collaboration in this context is a way of connecting and aligning our creative minds. We are always looking forward to collaborating with innovators, academics, federal labs, research institutes, startups, small and medium size companies and established businesses that value partnerships and would like to play an active role with us to ensure a sustainable future for everyone.

 

For more information about BASF's Polyurethanes, please visit: http://www.polyurethanes.basf.us/

 

 

 

“The Nexus Blog” is a sister publication of “The Nexus” newsletter. To sign up for the newsletter, please email gci@acs.org, or if you have an ACS ID, login to your email preferences and select “The Nexus” to subscribe.

 

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By www.launch.org

 

At LAUNCH we see a future where the making of things has a positive impact on human prosperity and planetary sustainability.

 

An Invitation for Innovators: Summary

 

Founding partners NASA, NIKE, the US Agency for International Development (USAID) and the US Department of State formed LAUNCH in an effort to bring collective genius, unprecedented networks, and new resources to overcome some of humanity’s toughest sustainability challenges.

 

With this LAUNCH System Challenge 2013, LAUNCH seeks innovations that will transform the system of fabrics to one that advances equitable global economic growth, drives human prosperity and replenishes the planet’s resources.

 

We are interested in innovations with potential to scale in 2 years, as well as game-changing early stage technologies and prototypes. Innovations can be business models, financial instruments, technologies and programs that accelerate research, education and capacity building.

 

Specifically, LAUNCH 2013 seeks innovations in:

 

  • The materials of which fabrics are made with a focus on positive social and environmental impact
    • Multi-purpose synthetic and bio-synthetic materials.
    • Smart and/or self-healing materials.
    • Technical fabrics with novel or surprising attributes.
    • Fabrics that efficiently and effectively enable recycling.
    • Applications that eliminate toxins in fabrics.
    • Low or positive environmental impact “feedstocks”.
    • Models that accelerate the development of low or positive environmental impact fabrics.
    • Data generation and capture technologies and mechanisms that enable traceability across a product or fabric’s lifecycle.
    • Decision support and educational tools that guide positive impact design and inform better choices of chemistries and materials.
    • Open technology platforms to enable sharing, collaboration, contribution and unlimited accessibility to data that improves the analysis of sustainability impacts and stimulates an open data ecosystem.

 

  • The “making” or manufacturing of fabrics utilizing low or positive environmental impact approaches, with a bias toward inclusive business models that positively develop human capital, respect rights and deliver shared value.
    • Solutions that increase energy, water, and raw material efficiency in the manufacturing process.
    • Solutions that put workers at the heart of the innovation process.
    • Zero waste or closed loop systems that eliminate waste and create equitable, empowered workforces.
    • Scalable innovative business models that are sustainable and equitable.
    • Manufacturing processes that reuse waste.
    • Programs that support local Micro, Small and Medium Enterprise inclusion across the system of fabrics.
    • Information and data exchanges that build entrepreneurial capacity & worker inclusion, enabling greater participation in value chains.
    • Data generation and capture technologies and mechanisms to increase transparency across the value chain.
    • Manufacturing processes and technologies that enable maximum conversion of materials and minimum consumption of natural resources.

 

To submit an innovation go to http://www.launch.org/challenges/systems-2013

 

 

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By Dr. Jennifer Young Tanir

ILSI Health and Environmental Sciences Institute

 

 

 

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When surveyed by the ILSI Health and Environmental Sciences Institute (HESI), there was general agreement by stakeholders that attributes beyond hazard are also important (i.e. LCA, risk/exposure, cost, performance, social responsibility) and no one tool or method meets all needs. There is not enough standardization with current methodologies and there is often insufficient handling of data gaps and insufficient ability to weigh multiple attributes.  The need to pool the expertise of participants across academia, government, NGOs, and industry to develop guidance for implementing alternatives assessment led HESI to initiate the Emerging Issues Subcommittee on Frameworks for Alternative Chemical Assessment and Selection of Safer, Sustainable Alternatives (i.e. Sustainable Alternatives subcommittee) in the fall of 2011.  The mission of the project is to evaluate and identify key elements/criteria and tools to help trigger and guide the selection of safer, sustainable alternatives while minimizing the likelihood of regrettable substitutions. The project aims to develop practical, problem driven guidance on the conduct of alternatives assessment that will address multi-stakeholder needs and go beyond hazard assessment.

 

 

Increasing pressures from consumers and regulators have led to efforts to find more sustainable, safer chemical alternatives. Alternatives Assessment is a process for identifying and comparing potential chemical and non-chemical alternatives that can be used as substitutes to replace chemicals or technologies of high concern (Dr. Ken Geiser of Lowell Center for Sustainable Production).  On the regulatory side, REACH, the California Safer Consumer Products Regulation, and potential TSCA reform are the main drivers requiring alternatives assessment. There are also incentives because of corporate sustainability initiatives, lists of chemicals of concern, eco-labels and certifications, and consumer preferences.

 

 

 

The HESI Sustainable Alternatives subcommittee has decided to focus on three challenging topics (through three subgroups), which will be presented at the 17th Annual Green Chemistry & Engineering Conference.  1) Attributes and Tools: this subgroup is focused on developing guidance on attributes beyond hazard that are also important, including life cycle assessment, exposure, risk, performance, cost and social responsibility, as well as new tools for prioritization and assessment of hazard, risk and other attributes.  2) Decision-making and Weighing: this subgroup has emphasized making decisions with limited data and a minimum data set and best practices for weighing disparate attributes. 3) Data Gaps: this subgroup is examining the data gaps, data needs, and solutions for missing data.  Much progress was made on the project during a recent HESI workshop on Developing Guidance for Alternatives Assessment (7-8 February 2013), featured in the Environmental Factor by the National Institute of Environmental Health Sciences (NIEHS) in the article “Public-private group explores sustainable alternatives assessment.”

 

 

To learn more about the guidance being developed on these three topics by the subcommittee, stop by presentations #43-45 during the 17th Annual Green Chemistry & Engineering Conference in the “What Is An Alternative Assessment?” session, on the afternoon of April 18.  HESI is also sponsoring the 3rd Annual ACS GCI Roundtable Poster Reception on June 17 and will be available to discuss their poster, materials, and the program.

 

 

 

The ILSI Health and Environmental Sciences Institute (HESI) was established in 1989 as a global branch of the International Life Sciences Institute (ILSI) to provide an international forum to advance the understanding of scientific issues related to human health, toxicology, risk assessment, and the environment. With a vision of creating science-based solutions for a sustainable, healthier world, HESI recognizes sustainability as vitally important as it identifies and resolves global health and environmental issues through engagement with scientists from academia, government and industry.  As a non-profit organization, HESI provides a unique, objective forum for initiating dialogue among scientists with different perspectives and expertise from a range of sectors including pharmaceuticals, agricultural and industrial chemicals, personal care and consumer product, and others. HESI’s broad scientific portfolio across 16 scientific committees spans advancing translational sciences, innovating novel approaches, and improving risk and safety evaluation. Using a committee structure to engage scientists, supported by expert staff with advanced scientific degrees, HESI enables hundreds of scientists to work together to address public health needs, from 49 corporate sponsors, 70 universities, 32 government agencies (international, national, and state), foundations and non-governmental organizations.  If you are interested in becoming involved with the HESI Sustainable Alternatives subcommittee or any other HESI scientific committee, contact Dr. Jennifer Young Tanir (jtanir@hesiglobal.org). Please visit the HESI website (www.hesiglobal.org) for more information.

 

 

 

 

“The Nexus Blog” is a sister publication of “The Nexus” newsletter. To sign up for the newsletter, please email gci@acs.org, or if you have an ACS ID, login to your email preferences and select “The Nexus” to subscribe.

 

To read other posts, go to Green Chemistry: The Nexus Blog home.

This past month I had the privilege to participate in the People, Prosperity & the Planet Competition sponsored by the U.S. EPA.  I am very grateful to be a part of these events to see the progress that is being made in colleges and universities to engage students across many disciplines in sustainability research.  In many ways, I am alternately thrilled and dismayed.  Thrilled by the number of projects that are just spot on; the students understand the problem, they are all engaged, and they are all contributing. Dismayed, because that experience is not a ubiquitous one; there are a lot of silos out there, and the educational establishment is not where it needs to be.  I applaud the EPA for sponsoring this competition and I applaud the students who demonstrated such vigor and commitment to doing their best in their work. I also applaud the judges who collectively bring such wisdom to the table, I learned a lot from them.

 

 

 

I also had the opportunity to speak at the Adhesives and Sealants Council spring meeting.  I had the great fortune to hear, once again, a few speakers whose work I admire.  Dr. George Thompson of Chemical Compliance Systems spoke on his GreenSuite products and their application to chemical alternatives assessment.  For those of you who are unfamiliar with the product, I would encourage you to take a look.  Dr. John Warner gave his usual entertaining and inspiring talk on the importance of Science and Innovation.  I’ve heard John speak many times now, and I very much appreciate the clarity of his message that we need to focus on science and innovation in green and sustainable chemistry.  Dr. Richard Wool was also there, and I am always delighted to see the breadth and creativity in his work.  The bottom line for me was that there continue to be an enormous number of opportunities in green and sustainable chemistry no matter what sector you focus on.

 

 

 

I was also pleased to host the spring meeting of our ACS GCI Governing Board last week.  It’s a privilege to have such a group of committed, accomplished and knowledgeable individuals available for extended discussion and planning.  We focused on some strategic planning this time around, given that the ACS GCI Staff, for the most part, is relatively new to  ACS GCI. I spent the preceding month digging into the history of the ACS GCI and all the strategic planning that has been done. We also completed a stakeholder review to give us a sense of the current state of sustainable and green chemistry. Compared to 2001, the sustainable and green chemistry space is much more crowded than it was, and that is a real testimony to many of you who have worked very hard over the past dozen years to move things forward.

 

 

 

So what was the outcome of the strategic planning?  The ACS GCI can’t do it all; there needs to be greater focus and fewer objectives. We’re going to keep the GC&E Conference going and we’re going to continue to make it better.  The Industrial Roundtables are unique, they’ve grown in influence and outcomes, and we need to do more to increase their size, number and influence.  In general, there is a need to set the research agenda and draw attention the grand challenges and how sustainable and green thinking needs to permeate all of the chemical enterprise.   There are many ways we can do that but we have some more work to do before we can talk about our ideas.

 

 

 

Stay tuned, but in the meantime, I hope to see many of you at the 17th Green Chemistry and Engineering Conference in North Bethesda, MD, June 18 – 20.  We’re looking forward to it and working very hard here to make it a great conference experience.

 

 

 

As always, let me know what you think.

 

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“The Nexus Blog” is a sister publication of “The Nexus” newsletter. To sign up for the newsletter, please email gci@acs.org, or if you have an ACS ID, login to your email preferences and select “The Nexus” to subscribe.

 

To read other posts, go to Green Chemistry: The Nexus Blog home.

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