ACS Green Chemistry Institute®

Chemistry in Water - Following Nature's Lead

Blog Post created by ACS Green Chemistry Institute® on Apr 19, 2018

The symposium "Chemistry in Water – Following Nature’s Lead" honors the winners of the 2018 Peter J. Dunn award by the ACS GCI Pharmaceutical Roundtable: Prof. Sachin Handa, University of Louisville, and Prof. Bruce Lipshutz, University of California, Santa Barbara. The Symposium features the latest developments in new synthetic chemistry from both academic and industrial labs that document not only that waste creation can be minimized, but that by going green, “faster, better, cheaper” processes oftentimes can be anticipated.

 

Prof. Sachin Handa’s award lecture "Non-Traditional Approaches to Chemical Catalysis to Sustainably Achieve Selective Reaction Pathways" will focus on issues with reproducibility, purity and selectivity arising at the multi-gram scale. In addressing these issues, Prof. Handa’s group has sought to develop catalysts, reagents and reaction media which are cheap, sustainable, easily recyclable, safer to use and yet also markedly improve reaction outcomes in terms of activity, selectivity and scalability.

 

Prof. Bruce Lipshutz’s award lecture "Synthetic Organic Chemistry in Water, Environmentally Responsible and Sustainable" will focus on the recent (unpublished) development of new palladacycles that are matched to both a ligand and their use in micellar catalysis, thereby enabling Suzuki-Miyaura (SM) cross-couplings at 300 ppm levels of Pd. A new ligand platform will also be discussed that can be prepared in only two steps, and that also can be applied to ppm level Pd-catalyzed SM reactions in water under mild conditions.

 

Dr. Wilfried Braje, Senior Principle Scientist at AbbVie, will give his presentation "Organic Chemistry in Water: Applications in the Pharmaceutical Industry" that will disclose applications of micellar catalysis for the most important reaction types performed in the pharmaceutical industry (e.g., transition-metal-catalyzed reactions such as Buchwald-Hartwig aminations, Suzuki, and Negishi couplings). In addition, a new additive will be disclosed for the first time. This additive enables chemical reactions to proceed in water with unprecedented short reaction times.

 

Dr. Fabrice Gallou, Principle Fellow at Novartis, will present a talk entitled "Alternative Solvents: From a Compliance-Driven Activity to a Trigger for Innovation" focusing on the application of the surfactant technology developed by professors Lipshutz and Handa. The team at Novartis has identified a variety of straightforward and highly advantageous transformations and their applications on-scale. Implementation of the technology typically resulted in significant benefits across their entire portfolio, not just from an environmental standpoint but also from an economic and productivity perspective (e.g., reduction in organic solvent consumption, water use and cycle time, milder reaction conditions, and improved yields and selectivities, which all contribute to improved process performance and lower manufacturing costs).

 

The Symposium will be held at the Green Chemistry & Engineering Conference in Portland on Monday, June 18, 2018, from 9:45 a.m. to 12:25 p.m.

Outcomes