• Using solutions calculator for making small amounts of solutions of hydrates

    Hello! Can someone please explain making solutions involving chemicals in hydrate form? I am using a calculator which has worked well for all chemicals except hydrates.   When using this calculator, I obtain dif...
    Dawn Keckley
    last modified by Dawn Keckley
  • Dye Chemist Lead Scientist Opportunity in NYC

      Role: Lead Scientist   Kinnos is a Brooklyn-based company founded by three Columbia alumni to protect healthcare workers and patients from infection. Their first product, Highlight, is an additive for dis...
  • Looking for chemist partner for new product used daily

    Hi - I'm looking to partner with a chemist, preferably demographically located near South Florida (but not 100% necessary) on a creating the proper elements of product that would really ease the way individuals and bu...
    Rich Ehmke
    last modified by Rich Ehmke
  • Inhibition of Sphingosine 1 Phosphate Receptor Inhibitor

    Sphingosine 1 phosphate receptor (S1PR) is a member of the G protein-coupled receptor (GPCR) family, which is mainly coupled with the G protein α subtype. Numerous studies in recent years have yielded a vari...
    Alex Dean
    created by Alex Dean
  • EGFR Inhibitors: Toxicities and Strategies

    Patients undergoing cancer treatments must often contend with the potentially life-threatening consequences of cytotoxic chemotherapy. Newer cancer treatments increasingly involve the use of targeted agents that inhib...
    Alex Dean
    created by Alex Dean
  • Pharmacological PKA Inhibition

    Signaling through the cyclic adenosine monophosphate–dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. This signaling pathway is commonly ...
    Alex Dean
    last modified by Alex Dean
  • Vesicular monoamine transporter 2 Inhibitor

    Methamphetamine abuse escalates, but no approved therapeutics are available to treat addicted individuals. Methamphetamine increases extracellular dopamine in reward-relevant pathways by interacting at vesicular monoa...
    Alex Dean
    created by Alex Dean
  • TSPO and diseases

    Clinical studies have found that the levels of TSPO in the brain of patients with different types of anxiety are lower than normal, and the content of TSPO in peripheral blood mononuclear cells and platelets is also s...
    Alex Dean
    created by Alex Dean
  • Trace amine-associated receptor 1 Inhibitor

    It is now recognized that Trace Amine Associated Receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research...
    Alex Dean
    created by Alex Dean
  • The Use of Thymidylate Synthase Inhibitors in the Treatment of Advanced Colorectal Cancer

    The Use of Thymidylate Synthase Inhibitors in the Treatment of Advanced Colorectal Cancer Enormous efforts have been made over the years to improve the efficacy of 5-FU, the most popular of these agents. Biochemical m...
    Alex Dean
    created by Alex Dean
  • Novel insight into the function of Tankyrase-1 Inhibitor

    Currently, researchers have synthesized two classical selective small molecule tankyrase-1 inhibitors, IWR 1 and XAV 939. IWR 1 inhibits the 50% inhibitory concentration (IC50) of tankyrase-1 to 131 nM. XAV 939 is an ...
    Alex Dean
    created by Alex Dean
  • Tau Fragments

    Fibers of fragments from the microtubule binding domain had a cross β-structure that closely resembles that reported both for neurofibrillary tangles found in Alzheimer's disease brain and for fibrous lesions fro...
    Cathy Miller
    created by Cathy Miller
  • Matrix Metalloproteinase Substrates

    Proteomics encompasses powerful techniques termed 'degradomics' for unbiased high-throughput protease substrate discovery screens that have been applied to an important family of extracellular proteases, the matrix me...
    Cathy Miller
    created by Cathy Miller
  • Diversity of Human Insulin-like Growth Factor (IGF) Binding Protein-2 Fragments

    The insulin-like growth factor binding proteins (IGFBPs) play a major role in the regulation of the effects and the bioavailability of the insulin-like growth factors (IGFs). IGFs are released from IGFBP−IGF com...
    Cathy Miller
    created by Cathy Miller
  • Can Pancreastatin Predict Survival in Neuroendocrine Tumors?

    Serum neurokinin A, chromogranin A, serotonin, and pancreastatin reflect tumor burden in neuroendocrine tumors. We sought to determine whether their levels correlate with survival in surgically-managed small bowel (SB...
    Cathy Miller
    created by Cathy Miller
  • Gastric Inhibitory Polypeptide

    Gastric inhibitory peptide (GIP) is a member of the secretin family of hormones. It was discovered as a factor in extracts of intestine that inhibited gastric motility and secretion of acid, and initially called enter...
    Cathy Miller
    created by Cathy Miller
  • Checkpoint Inhibitors for Cancer Therapy: Clinical Efficacy and Safety.

    A major breakthrough in cancer immunotherapy was the discovery of immune checkpoint proteins, which function to effectively inhibit the immune system through various mechanisms. The first of such molecules shown to in...
    Cathy Miller
    created by Cathy Miller
  • How to choose an effective protein bioconjugation strategy

    Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. The collection of chemical techniques that can be used to attach synthetic group...
    Cathy Miller
    last modified by Cathy Miller
  • Stem Cells and Cell Therapy

    Cell therapy is an emerging therapy with great therapeutic potential because, unlike small molecules, cells are a dynamic product. They can migrate, proliferate, differentiate, and respond to their environment both in...
    Cathy Miller
    created by Cathy Miller
  • Academic Specialist Position @ Michigan State University

    The Department of Chemistry at Michigan State University is currently searching for an academic specialist whose responsibilities will include undergraduate advising, program administration and assessment, and partici...
    Michael Davis
    created by Michael Davis