Publication Details (including relevant citation information):
Feher, Domonkos; Barlow, Russell S.; Lorenzo, Patricia S.; Hemscheidt, Thomas K. Journal of Natural Products (2008), 71(11), 1970-1972. CODEN: JNPRDF ISSN:0163-3864. CAN 149:528348 AN 2008:1250406 CAPLUS
In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this extract resulted in the isolation of a series of known and new prodiginine-type azafulvenes. The structure of the major metabolite was elucidated by interpretation of spectroscopic data as a 2 substituted prodigiosin, which we named 2-(p-hydroxybenzyl)prodigiosin (HBPG).