Roberto Marin - Potentially Deadly Carcinogenic Chromium Redox Cycle Involving Peroxochromium(IV) and Glutathione

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  Publication Details (including relevant citation   information):

  Roberto Marin, Yachna Ahuja and Rathindra N. Bose J. Am.   Chem. Soc. 2010, 132, 1017-10619.


  Peroxochromium(IV) complexes are putative DNAdamaging and   mutagenic agents in chromium(VI)-mediated carcinogenesis. The   reaction between aquaethylenediaminebis(peroxo)
  chromium(IV) and glutathione at neutral pH exhibits a cyclic   redox process displaying a persistent recycling of Cr(IV) and   Cr(VI) with the intervention of chromium(V) intermediates.   The
  coordination by a glutathione molecule triggers an autooxidation   of the Cr(IV)-peroxo complex to Cr(VI) via an internal   electrontransfer process followed by reduction to Cr(IV) via   metastable
  chromium(V) intermediates. The cycle is repeated by the second   peroxo species. The Cr(V) and -(IV) intermediates have been   characterized as mono- and bisglutathionato complexes with or
  without a coordinated peroxo moiety. These intermediates are   capable of damaging DNA, as evidenced by single strand breaks and   DNA oxidation. The implication here is that the potential for
  a persistent, if not perpetual, deadly chromium carcinogenic   cycle exists in the cellular milieu through the assistance of   molecular oxygen and glutathione.

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