Kathirvel Ganesan - J. Mater. Chem., 2008, 18, 3655 - 3661, DOI: 10.1039/b805366a "Calcium phosphate nanoparticles: colloidally stabilized and made fluorescent by a phos

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  Publication Details (including relevant citation   information): J. Mater. Chem., 2008, 18, 3655 - 3661,   DOI: 10.1039/b805366a "Calcium phosphate nanoparticles:   colloidally stabilized and made fluorescent by a   phosphate-functionalized porphyrin" Kathirvel Ganesan, Anna   Kovtun, Sebastian Neumann, Rolf Heumann and Matthias Epple*   Abstract: Calcium phosphate nanoparticles were prepared by   precipitation and colloidally stabilized by surface   functionalization with   5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (p-TPPP). No   other stabilizing agents were necessary, and all dissolved   counter-ions and excess porphyrin were removed by   ultracentrifugation. The resulting porphyrin-functionalized   nanoparticles were spherical with a diameter of about 250 nm. The   adsorption of porphyrin on the calcium phosphate surface was   confirmed by IR spectroscopy and quantified by elemental analysis   (the loading was about 4-;5 wt% porphyrin). In a cell culture   with NIH 3T3 fibroblast cells, the particles showed excellent   biocompatibility (confirmed by an MTT test), and their uptake   into the cells could be followed by confocal laser scanning   microscopy. Hence, these biocompatible nanoparticles may be used   as biocompatible fluorescing agents or for the delivery of   fluorescing molecules.

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  Address (URL): http://www.rsc.org/publishing/journals/JM/article.asp?doi=b805366a