Publication Details (including relevant citation information):
D.Giribone, F.Orzi and E.Fontana
Journal of Labelled Compounds and Radiopharmaceuticals, (1997) 40:397-9
The synthesis of the title compound labelled with carbon-14 in the polymeric chain is reported. MAG-Taxol, laboratory code PNU-166945, is a synthetic hydroxypropyl-methacrylamide copolymer bearing an aminoacidic side chain linked through an esteric bound at the 2’ position of the taxol C13 side chain. A three step sequence, starting from the commercially available [14C]methacrylic acid, led to the radiochemically pure final compound with a specific activity of 281 KBq/mg. The overall radiochemical yield was 20%.
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