Publication Details (including relevant citation information): Glucose-lowering properties of vanadium compounds: comparison of coordination complexes with maltol or kojic acid as ligands. Yuen, Violet G.; Caravan, P.; Gelmini, Lucio; Glover, Nicholas; Mcneill, John H.; Setyawati, Ika A.; Zhou, Ying; Orvig, Chris. Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Can. J. Inorg. Biochem. (1997), 68(2), 109-116. CODEN: JIBIDJ ISSN: 0162-0134. Journal written in English. CAN 127:341613 AN 1997:675191 CAPLUS (Copyright 2002 ACS) Abstract Bis(kojato)oxovanadium(IV) [VO(ka)2], a close chem. analog of the insulin-mimetic lead compd. bis(maltolato)oxovanadium(IV) [BMOV, VO(ma)2] is reported and its reaction chem. and insulin-mimetic properties are presented. VO(ka)2 [log K1 = 7.61(10), log K2 = 6.89(6), log 2 = 14.50(16)] has a reaction chem. which directly parallels that of VO(ma)2. In aq. soln. it is more slowly oxidized by mol. oxygen to [VO2(ka)2]- than is VO(ma)2 to [VO2(ma)2]-. Variable pH electrochem. and variable pH51V NMR of solns. of VO(ka)2 are presented and contrasted with the corresponding results for VO(ma)2. Time course studies (24 h) in STZ-diabetic rats following the oral or i.p. administration of VO(ka)2, VO(ma)2, VO2+ (vanadyl) as vanadyl sulfate (VOSO4), and [VO2(ma)2]- as its [NH4]+ salt have been performed, as have chronic oral studies comparing VO(ka)2 and VO(ma)2 over a six week period. In all studies, the most potent form of vanadium was the neutrally charged, water sol., complex VO(ma)2. Bibliographic Information Reaction chemistry of BMOV, bis(maltolato)oxovanadium(IV), a potent insulin mimetic agent. Orvig, Chris; Caravan, P.; Gelmini, Lucio; Glover, Nicholas; Herring, F. Goeffrey; Li, Huali; McNeill, John H.; Rettig, Steven J.; Setyawati, Ika A.; et al. Department of Chemistry, University of British Columbia, Vancouver, BC, Can. J. Am. Chem. Soc. (1995), 117(51), 12759-70. CODEN: JACSAT ISSN: 0002-7863.