Lucio Gelmini - Glucose-lowering properties of vanadium compounds: comparison of coordination complexes with maltol or kojic acid as ligands.     Yuen, Violet G.; Caravan, P

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      Publication Details (including relevant citation   information): Glucose-lowering properties of vanadium   compounds: comparison of coordination complexes with maltol or   kojic acid as ligands. Yuen, Violet G.; Caravan, P.; Gelmini,   Lucio; Glover, Nicholas; Mcneill, John H.; Setyawati, Ika A.;   Zhou, Ying; Orvig, Chris. Faculty of Pharmaceutical Sciences,   University of British Columbia, Vancouver, BC, Can. J. Inorg.   Biochem. (1997), 68(2), 109-116. CODEN: JIBIDJ ISSN: 0162-0134.   Journal written in English. CAN 127:341613 AN 1997:675191 CAPLUS   (Copyright 2002 ACS) Abstract Bis(kojato)oxovanadium(IV)   [VO(ka)2], a close chem. analog of the insulin-mimetic lead   compd. bis(maltolato)oxovanadium(IV) [BMOV, VO(ma)2] is reported   and its reaction chem. and insulin-mimetic properties are   presented. VO(ka)2 [log K1 = 7.61(10), log K2 = 6.89(6), log 2 =   14.50(16)] has a reaction chem. which directly parallels that of   VO(ma)2. In aq. soln. it is more slowly oxidized by mol. oxygen   to [VO2(ka)2]- than is VO(ma)2 to [VO2(ma)2]-. Variable pH   electrochem. and variable pH51V NMR of solns. of VO(ka)2 are   presented and contrasted with the corresponding results for   VO(ma)2. Time course studies (24 h) in STZ-diabetic rats   following the oral or i.p. administration of VO(ka)2, VO(ma)2,   VO2+ (vanadyl) as vanadyl sulfate (VOSO4), and [VO2(ma)2]- as its   [NH4]+ salt have been performed, as have chronic oral studies   comparing VO(ka)2 and VO(ma)2 over a six week period. In all   studies, the most potent form of vanadium was the neutrally   charged, water sol., complex VO(ma)2. Bibliographic Information   Reaction chemistry of BMOV, bis(maltolato)oxovanadium(IV), a   potent insulin mimetic agent. Orvig, Chris; Caravan, P.; Gelmini,   Lucio; Glover, Nicholas; Herring, F. Goeffrey; Li, Huali;   McNeill, John H.; Rettig, Steven J.; Setyawati, Ika A.; et al.   Department of Chemistry, University of British Columbia,   Vancouver, BC, Can. J. Am. Chem. Soc. (1995), 117(51), 12759-70.   CODEN: JACSAT ISSN: 0002-7863.

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