Naraso Borjigin - Abstracts of Papers of the American Chemical Society

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      Publication Details (including relevant citation   information):

      2010,   N502

      Authors: Naraso Borjigin, and Luke Theogarajan


      ABA polymer.JPG

      Recently, there has been an increasing interest in the design of   self-assembling polymeric nano-containers for drug delivery   purposes. A variety of amphiphilic block copolymers have been   studied. Although there has been much research on the use of   polymeric materials for structural purposes, such as in drug   delivery systems, biocompatible coatings and as matrices for   reconstitution of biomolecules, there has been little attention   paid to self-assembling polymeric membranes that incorporate   functionality as an integral part of the membrane. In our   previous work, we have reported   poly[(dimethylsiloxanecomethylhydrosiloxane)- block-oxazoline]   ABA triblock copolymers derivatized with methyl benzoate and   18-crown-6 ether supramolecules

      via hydrosilylation reactions. The pendant groups of 18-crown-6   are of interest in the biomedical realm for the recognition and   transport of potassium ions. The synthesized triblocks have been   electroformed into vesicles. Vesicle size seems to correlate with   side-chain lipophilicity.

      Side-chain receptor density does not seem to affect the   self-assembling properties of these polymeric membranes. In this   study, we have synthesized a series of new triblock polymers by   using a new tosylterminated ester siloxane end-blocker that   serves as molecular weight

      control in the synthesis of polydimethylsiloxane (PDMS) and   poly(dimethylsiloxaneco-methylhydrosiloxane) [P(DMS-co-MHS)]   copolymers. The triblock polymers were further derivatized with   undecanoic acid tert-butyl ester via hydrosilylation reactions   and were

      converted to undecanoic acid by deprotection.

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