Publication Details (including relevant citation information):
Authors: Naraso Borjigin, and Luke Theogarajan
Recently, there has been an increasing interest in the design of self-assembling polymeric nano-containers for drug delivery purposes. A variety of amphiphilic block copolymers have been studied. Although there has been much research on the use of polymeric materials for structural purposes, such as in drug delivery systems, biocompatible coatings and as matrices for reconstitution of biomolecules, there has been little attention paid to self-assembling polymeric membranes that incorporate functionality as an integral part of the membrane. In our previous work, we have reported poly[(dimethylsiloxanecomethylhydrosiloxane)- block-oxazoline] ABA triblock copolymers derivatized with methyl benzoate and 18-crown-6 ether supramolecules
via hydrosilylation reactions. The pendant groups of 18-crown-6 are of interest in the biomedical realm for the recognition and transport of potassium ions. The synthesized triblocks have been electroformed into vesicles. Vesicle size seems to correlate with side-chain lipophilicity.
Side-chain receptor density does not seem to affect the self-assembling properties of these polymeric membranes. In this study, we have synthesized a series of new triblock polymers by using a new tosylterminated ester siloxane end-blocker that serves as molecular weight
control in the synthesis of polydimethylsiloxane (PDMS) and poly(dimethylsiloxaneco-methylhydrosiloxane) [P(DMS-co-MHS)] copolymers. The triblock polymers were further derivatized with undecanoic acid tert-butyl ester via hydrosilylation reactions and were
converted to undecanoic acid by deprotection.