Martin Lang - Substituted 2-Arylbenzothiazoles as Kinase Inhibitors: Hit-to-Lead Optimization

Document created by Martin Lang on Aug 22, 2014
Version 1Show Document
  • View in full screen mode

  Publication Details (including relevant citation   information):

  Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Stefano   Pegoraro, Wael Saeb, Martin Lang, Rolf Krauss, Frank Totzke, Ute   Zirrgiebel, Jan E. Ehlert, Michael H. G. Kubbutat, Christoph   Schächtele

  Abstract:

  Based on an (aminoaryl)benzothiazole quinazoline hit structure   for kinase inhibition, a systematic optimization program resulted   in a lead structure allowing for inhibitory activities in   cellular phosphorylation assays in the low nanomolar range.

  Co-Authors:
  Tasler

  Address (URL): http://dx.doi.org/10.1016/j.bmc.2009.07.047

 

Attachments

    Outcomes