Martin Lang - Substituted 2-Arylbenzothiazoles as Kinase Inhibitors: Hit-to-Lead Optimization

Version 1

      Publication Details (including relevant citation   information):

      Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Stefano   Pegoraro, Wael Saeb, Martin Lang, Rolf Krauss, Frank Totzke, Ute   Zirrgiebel, Jan E. Ehlert, Michael H. G. Kubbutat, Christoph   Schächtele

      Abstract:

      Based on an (aminoaryl)benzothiazole quinazoline hit structure   for kinase inhibition, a systematic optimization program resulted   in a lead structure allowing for inhibitory activities in   cellular phosphorylation assays in the low nanomolar range.

      Co-Authors:
      Tasler

      Address (URL): http://dx.doi.org/10.1016/j.bmc.2009.07.047