Rand Schwartz - Tight binding inhibitors of scytalone dehydratase: effects of site-directed mutations.

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      Publication Details (including relevant citation   information):

      Basarab, G. S., Jordan, D. B., Gehret, T. C., and Schwartz, R. S.   (2002) Design of inhibitors of scytalone dehydratase: probing the   interactions with an asparagine carboxamide. Bioorg. Med.   Chem.  10, 4143-4154.
        
      Basarab, G. S., Jordan, D. B., Gehret, T. C., Schwartz, R. S.,   Bonman, J. M., and Smith, G. S. (2002) Design of scytalone   dehydratase inhibiting rice blast fungicides. Synthesis and   Chemistry of Agrochemicals VI. American Chemical Society,   Washington, DC, pp. 278-291.

      Jordan, D. B., Basarab, G. S., Steffens, J. J., Schwartz, R. S.,   and Doughty, J. G. (2000) Tight binding inhibitors of scytalone   dehydratase: effects of site-directed mutations. Biochemistry 39,   8593-8602.

      Jennings, L. D., Rayner, D. R., Jordan, D. J., Okonya, J. F.,   Basarab, G. S., Amorose, D. K., Anaclerio, B. M., Lee, J. K.,   Schwartz, R. S., and Whitmore, K. A. (2000) Cyclobutane   carboxamide inhibitors of fungal melanin: biosynthesis and their   evaluation as fungicides.  Bioorg. Med. Chem. 8,   897-907.
       
      Jennings, L. D., Wawrzak, Z., Amorose, D., Schwartz, R. S., and   Jordan, D. B. (1999) A new potent inhibitor of fungal melanin   biosynthesis identified through combinatorial chemistry. Bioorg.   Med. Chem. Lett. 9, 2509-2514.

      Jordan, D. B., Kranis, K. T., Picollelli, M. A., Schwartz, R. S.,   Sternberg, J. A., and Sun, K. M. (1999) Famoxadone and   oxazolidinones: potent inhibitors of cytochrome bc1. Biochem.   Soc. Trans. 27, 577-580.

      Basarab, G. S., Jordan, D. B., Gehret, T. C., Schwartz, R. S.,   and Wawrzak, Z. (1999) Design of scytalone dehydratase inhibitors   as rice blast fungicides: derivatives of norephedrine. Bioorg.   Med. Chem. Lett. 9, 1613-1618.

      Jordan, D. B., Lessen, T. A., Wawrzak, Z., Bisaha, J. J., Gehret,   T. C., Hansen, S. L., Schwartz, R. S., and Basarab, G. S. (1999)   Design of scytalone dehydratase inhibitors as rice blast   fungicides: 
      (N-phenoxypropyl)-carboxamides. Bioorg. Med. Chem. Lett. 9,   1607-1612.

      Basarab, G. S., Steffens, J. J., Wawrzak, Z., Schwartz, R. S.,   Lundqvist, T., and Jordan, D. B. (1999) Catalytic mechanism of   scytalone dehydratase: site-directed mutagenesis, kinetic isotope   effects, and alternate substrates. Biochemistry 38, 6012-6024.

      Jordan, D. B., Basarab, G. S., Steffens, J. J., Lundqvist, T.,   Pfrogner, B. R., Schwartz, R. S., and Wawrzak, Z. (1999)   Catalytic mechanism of scytalone dehydratase from Magnaporthe   grisea.  Pestic. Sci. 55, 277-280.

      Steffens, J. J., Basarab, G. S., Schwartz, R. S., Lundqvist, T.,   Wawrzak, Z., and Jordan, D. B. (1999) Substrate and inhibitor   binding by scytalone dehydratase, a target of rice blast   fungicides.  Modern Fungicides and Antifungal Compounds II   (Lyr, H., Russell, P. E., Dehne, H. W., and Sisler, H. D. eds.),   121-130. Intercept Ltd, Andover, Hampshire, UK.

      Jordan, D. B., Livingston, R. S., Bisaha, J. J., Duncan, K. E.,   Pember, S. O., Picollelli, M. A., Schwartz, R. S., Sternberg, J.   A., and Tang, X.S. (1999) Oxazolidinones: a new chemical class of   fungicides and inhibitors of mitochondrial cytochrome bc1   function.   Pestic. Sci. 55, 213-215.

      Jordan, D. B., Livingston, R. S., Bisaha, J. J., Duncan, K. E.,   Pember, S. O., Picollelli, M. A., Schwartz, R. S., Sternberg, J.   A., and Tang, X.S. (1999) Mode of action of famoxadone. Pestic.   Sci. 55, 105-118.

      Jordan, D., Viitanen, P., Wawrzak, Z., Picollelli, M., Bacot, K.,   Schwartz, R., and Thompson, J. (1997) Cloning, overexpression,   crystallization, and some kinetic studies on E. coli riboflavin   synthase. Flavins and Flavoproteins 1996 (Stevenson, K. J.,   Massey, V., and Williams, C. H. eds.), 945-948. University of   Calgary Press, Calgary, Canada.

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