Danilo Giribone - Labeled Taxanes

Version 1

      Publication Details (including relevant citation   information):

      D.Giribone,   E.Fontana

      International application   WO/2003/080587, 02 October 2003 (priority date 21 March   2002)

      Abstract:

      There are provided stable labelled taxanes, characterized in that   the isotopes are present in the benzoyloxy group at the C-2   position. More particularly, one or more of the hydrogen or   carbon atoms of the benzoyl residue at the C-2 position of the   taxane skeleton is replaced respectively from deuterium or   13C. A process for their preparation and their use as   internal standard in analytical methods for determining taxanes,   useful anticancer drugs, are also provided.

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