Publication Details (including relevant citation information):
D.Giribone, A.Pignatti, E.Fontana
International application WO/2004/012776, 12 February 2004 (priority date August 1, 2002)
The present invention relates to indolinone derivatives and, more particularly, it relates to the above compounds isotopically labelled with carbon 14 [14C], and to a process for their preparation. From the above, we have now found a new class of indolylidene-methyl-pyrroles being isotopically labelled with [14C] at the methylidene moiety. Because of their use in therapy, for instance in the treatment of cancer, the possibility of their preparation as isotopically labelled carbon 14 [14C] compounds is of utmost importance for absorption, distribution, metabolism and excretion (ADME) studies.
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