Danilo Giribone - Labelled Camptothecines

Version 1

      Publication Details (including relevant citation   information):

      D.Giribone,   N.Barbugian, R.Forino and E.Fontana

      International application   WO2004/056398, 8 July 2004 (priority date December 20,   2002)

      Abstract:

      The present invention pertains to the field of isotopically   labeled compounds useful in the absorption, distribution,   metabolism, excretion (ADME), pharmacokinetic and pharmacodynamic   studies. The invention relates to, in particular, the preparation   of stable labeled camptothecin analogs starting from commercially   available stable labeled precursors at high isotopic   enrichment.The present invention provides isotope stable labeled   camptothecin analogs including irinotecan and SN-38, a process   for their preparation and their use as internal standard in   analytical methods.

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