Publication Details (including relevant citation information):
D.Giribone, N.Barbugian, R.Forino and E.Fontana
International application WO2004/056398, 8 July 2004 (priority date December 20, 2002)
The present invention pertains to the field of isotopically labeled compounds useful in the absorption, distribution, metabolism, excretion (ADME), pharmacokinetic and pharmacodynamic studies. The invention relates to, in particular, the preparation of stable labeled camptothecin analogs starting from commercially available stable labeled precursors at high isotopic enrichment.The present invention provides isotope stable labeled camptothecin analogs including irinotecan and SN-38, a process for their preparation and their use as internal standard in analytical methods.
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