Publication Details (including relevant citation information):
J. Am. Chem. Soc., 2003, 125 (47), 14294-14295.
A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki−Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.
Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja038547b