Chihiro Tsukano - Total Synthesis of Gymnocin-A

Document created by Chihiro Tsukano on Aug 22, 2014
Version 1Show Document
  • View in full screen mode

  Publication Details (including relevant citation   information):

  J. Am. Chem. Soc., 2003, 125  (47), 14294-14295.

  Abstract:

  A highly convergent total synthesis of gymnocin-A, a   cyctotoxic    polyether marine natural product,   has been achieved. The synthesis    features   Suzuki−Miyaura coupling of the ABCD and FGHIJKLMN   rings,    stereoselective introduction of the C17   hydroxyl group, ring-closure  of   the F ring, and   a late-stage incorporation of a 2-methyl-2-butenal    side   chain.

  Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja038547b

 

Attachments

    Outcomes