Chihiro Tsukano - Total Synthesis of Gymnocin-A

Version 1

      Publication Details (including relevant citation   information):

      J. Am. Chem. Soc., 2003, 125  (47), 14294-14295.

      Abstract:

      A highly convergent total synthesis of gymnocin-A, a   cyctotoxic    polyether marine natural product,   has been achieved. The synthesis    features   Suzuki−Miyaura coupling of the ABCD and FGHIJKLMN   rings,    stereoselective introduction of the C17   hydroxyl group, ring-closure  of   the F ring, and   a late-stage incorporation of a 2-methyl-2-butenal    side   chain.

      Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja038547b