Chihiro Tsukano - Total Synthesis of Gymnocin-A

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  Publication Details (including relevant citation   information):

  J. Am. Chem. Soc., 2003, 125  (47), 14294-14295.


  A highly convergent total synthesis of gymnocin-A, a   cyctotoxic    polyether marine natural product,   has been achieved. The synthesis    features   Suzuki−Miyaura coupling of the ABCD and FGHIJKLMN   rings,    stereoselective introduction of the C17   hydroxyl group, ring-closure  of   the F ring, and   a late-stage incorporation of a 2-methyl-2-butenal    side   chain.

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