Publication Details (including relevant citation information):
Carbohydrate Polymers (1997), 33(1), 5-11
Ovine, porcine and bovine heparin were compared by NMR, disaccharide compn., optical rotation, elemental analyses, HPSEC and USP analyses. There were some differences found in the NMR and disaccharide compn. of the heparins. Ovine heparin contained less monosulfated and disulfated disaccharides than porcine or bovine mucosal heparins. The heparins were approx. equiv. in USP activity. Low mol. wt. ovine, porcine and bovine heparin were prepd. by both nitrous acid and copper/peroxide depolymn. Products were compared to each other and to Fragmin by disaccharide compn., optical rotation, HPSEC, NMR, elemental analyses, and the USP assay for anticoagulant activity. The low mol. wt. products showed a greater similarity to each other than to the parent heparins and it was concluded that the species of origin of a low mol. wt. heparin would be difficult to det. by these methods alone.
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