Vasudeva Sagi - Total Synthesis of Microcarpalide

Document created by Vasudeva Sagi on Aug 22, 2014
Version 1Show Document
  • View in full screen mode

  Publication Details (including relevant citation   information):

  J. Org. Chem. 2005, 70, 4207


  An efficient, convergent approach for the total synthesis of   microcarpalide (1) is described. The synthetic   strategy features the Sharpless asymmetric dihydroxylation,   regioselective epoxide opening with various nucleophiles such as   a lithium acetylide and cuprates derived from the vinyl stannane   and the vinyl iodide for the construction of a C7−C8   trans-double bond and Yamaguchi macrolactonization as   the key steps.

  Address (URL): HistoryKey=