Vasudeva Sagi - A Simple and Efficient Approach to 1,3-Polyols: Application to the Synthesis of Cryptocarya diacetate

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      Publication Details (including relevant citation   information):

      Chem. Eur. J. 2005, 12,   1397-1402.


      A highly enantio- and stereoselective synthetic strategy for both   syn- and anti-1,3-polyols has been developed. The sequence   involves iterative Jacobsen's hydrolytic kinetic resolution   (HKR), diastereoselective iodine-induced electrophilic   cyclization, and ring-closing metathesis (RCM). This protocol has   subsequently been utilized for the synthesis of cryptocarya   diacetate, a natural product with broad range of biological   activity.

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