Pamela Scott - 5,7-Diphenyl-3-ureidohexahydroazepin-2-ones as cholecystokinin-B receptor

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      Publication Details (including relevant citation   information):

      Bioorganic & Medicinal Chemistry Letters (1994), 4(24),   2877-82


      A series of 5,7-diphenyl-3-ureidohexahydroazepin-2-one   cholecystokinin-B
           (CCK-B) receptor antagonists was   synthesized using Beckmann ring expansion
           of a suitable 2,4-diphenylcyclohexanone   as a key step.  Structure-activity
           relationship studies revealed the   importance of the 5-aryl group for high
           and selective CCK-B receptor affinity,   as illustrated in compd. (-)-I
           (CCK-B IC50 = 6.8 mM).

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