Jason Perman - Asymmetric Co(II)-Catalyzed Cyclopropanation with Succinimidyl Diazoacetate: General Synthesis of Chiral Cyclopropyl Carboxamides

Version 1

      Publication Details (including relevant citation   information):

      Joshua V. Ruppel, Ted J. Gauthier, Nicole L. Snyder, Jason A.   Perman and Peter X. Zhang

      Abstract:

      [Co(P1)] is an effective catalyst for asymmetric cyclopropanation   with  succinimidyl diazoacetate. The Co(II)-catalyzed   reaction is suitable for  various olefins, providing the   desired cyclopropane succinimidyl esters  in high yields and   excellent diastereo- and enantioselectivity. The  resulting   enantioenriched cyclopropane succinimidyl esters can serve   as  convenient synthons for the general synthesis of   optically active  cyclopropyl carboxamides.

      Address (URL): http://pubs.acs.org/doi/full/10.1021/ol9005882