Jason Perman - Norselic Acids A-E, Highly Oxidized Anti-infective Steroids that Deter Mesograzer Predation, from the Antarctic Sponge Crella sp.

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      Publication Details (including relevant citation   information):

      Wai S. Ma, Tina Mutka, Brian Vesley, Margaret O. Amsler, James B.   McClintock, Charles D. Amsler, Jason A. Perman, Maya P. Singh,   William M. Maiese, Michael J. Zaworotko, Dennis E. Kyle and Bill   J. Baker

      Abstract:

      Five new steroids, norselic acids A-E (1-5), were isolated from   the  sponge Crella sp. collected in Antarctica. The planar   structures of the  norselic acids were established by   extensive NMR spectroscopy and mass  spectrometry studies,   and the configuration of norselic acid A (1) was  elucidated   by X-ray crystallography. Norselic acid A displays   antibiotic  activity against methicillin-resistant   Staphylococcus aureus (MRSA),  methicillin-sensitive S.   aureus (MSSA), vancomycin-resistant  Enterococcus faecium   (VRE), and Candida albicans and reduces consumption  of food   pellets by sympatric mesograzers. Compounds 1-5 are also   active  against the Leishmania parasite at low micromolar   levels.

      Address (URL): http://pubs.acs.org/doi/full/10.1021/np900382x