Publication Details (including relevant citation information):
Wai S. Ma, Tina Mutka, Brian Vesley, Margaret O. Amsler, James B. McClintock, Charles D. Amsler, Jason A. Perman, Maya P. Singh, William M. Maiese, Michael J. Zaworotko, Dennis E. Kyle and Bill J. Baker
Five new steroids, norselic acids A-E (1-5), were isolated from the sponge Crella sp. collected in Antarctica. The planar structures of the norselic acids were established by extensive NMR spectroscopy and mass spectrometry studies, and the configuration of norselic acid A (1) was elucidated by X-ray crystallography. Norselic acid A displays antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive S. aureus (MSSA), vancomycin-resistant Enterococcus faecium (VRE), and Candida albicans and reduces consumption of food pellets by sympatric mesograzers. Compounds 1-5 are also active against the Leishmania parasite at low micromolar levels.
Address (URL): http://pubs.acs.org/doi/full/10.1021/np900382x