Pamela Scott - 2-Chloro-1,1-triethoxy-ethane and Its Use In a Versatile Synthesis of Substituted, 2-Chloromethyl Heterocycles Including Benzothiazole and Benzoxazole.

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  Publication Details (including relevant citation   information):

  Synthetic Communications (1989), 19(16), 2921-4


  ClCH2(C(OEt)3 (I) was prepd. by chlorination of CH3C(OEt)3 with   N-chlorosuccinimide.  I underwent cyclocondensation   reactions with aminophenols or -thiophenols to afford   benzoxazoles or benzothiazoles II (X = O, S; Rn = H, 5-Br, 5- or   6-CF3, 5,7-F2, etc.).  I and 3-amino-2-mercaptopyridine or   2-amino-3-hydroxypyridine gave   2-chloromethylthiazolo[5,4-b]pyridine or -oxazolo[4,5-b]pyridine,   resp.

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