Wesley Chong - Synthesis of novel nitric oxide (NO)-releasing esters of timolol

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  Publication Details (including relevant citation   information):

  Chiroli, V.; Batugo, M. R.; Biondi, S.; Bonfanti, A.; Brambilla,   S.; Gale, D. C.; Li, L.; Miglietta, D.; Nicoli, F.; Prasanna, G.   A.; Ronchetti, D.; Vernier, W. F.; Chong, W. K.M., Synthesis of   novel nitric oxide (NO)-releasing esters of timolol. Bioorg Med   Chem Lett 2009, 19 (10), 2785-8.


  A novel class of timolol derivatives with nitric oxide   (NO)-donating moieties achieved chemical stability yet under   physiologically relevant conditions released timolol and NO.   Hindered esters A were designed and synthesized, whose   'triggered' release relied on enzymatic hydrolysis of the nitrate   ester in A to B, that in turn cyclized to liberate timolol.

  Address (URL): http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4VXTSGF-2&_user=1 0&_coverDate=05%2F15%2F2009&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=& v iew=c&_acct=C000050221&_version=1&_urlVe