Courtney Thomas - Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles

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      Publication Details (including relevant citation   information):

      Thomas, C.R.; Ferris, D.P.; Lee, J.-H.; Choi, E.; Cho, M.H.; Kim,   E.S.; Stoddart, J.F.; Shin, J.-S.; Cheon, J.; Zink, J.I. J.   Am. Chem. Soc. 2010, 132(31),   10623.

      Abstract:

      Mesoporous silica nanoparticles are useful nanomaterials that   have demonstrated the ability to contain and release cargos with   mediation by gatekeepers.  Magnetic nanocrystals have the   ability to exhibit hyperthermic effects when placed in an   oscillating magnetic field.  In a system combining these two   materials and a thermally sensitive gatekeeper, a unique drug   delivery system can be produced.  A novel material that   incorporates zinc-doped iron oxide nanocrystals within a   mesoporous silica framework that has been surface-modified with   pseudorotaxanes is described.  Upon application of an AC   magnetic field, the nanocrystals generate local internal heating,   causing the mol. machines to disassemble and allowing the cargos   (drugs) to be released.  When breast cancer cells   (MDA-MB-231) were treated with doxorubicin-loaded particles   and exposed to an AC field, cell death occurred.  This   material promises to be a noninvasive, externally controlled drug   delivery system with cancer-killing properties.

      Address (URL): http://pubs.acs.org/doi/full/10.1021/ja1022267