Antoine Taly - Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.

Version 1

      Publication Details (including relevant citation   information):

      Nat Rev Drug Discov. 2009 Sep;8(9):733-50.

      Taly A, Corringer PJ, Guedin D, Lestage P, Changeux   JP.

      Abstract:

      Nicotinic receptors - a family of ligand-gated ion channels that   mediate the effects of the neurotransmitter acetylcholine - are   among the most well understood allosteric membrane proteins from   a structural and functional perspective. There is also   considerable interest in modulating nicotinic receptors to treat   nervous-system disorders such as Alzheimer's disease,   schizophrenia, depression, attention deficit hyperactivity   disorder and tobacco addiction. This article describes both   recent advances in our understanding of the assembly, activity   and conformational transitions of nicotinic receptors, as well as   developments in the therapeutic application of nicotinic receptor   ligands, with the aim of aiding novel drug discovery by bridging   the gap between these two rapidly developing fields.

      Address (URL): http://www.nature.com/nrd/journal/v8/n9/full/nrd2927.html