Publication Details (including relevant citation information):
Source: Angewandte Chemie-International Edition Volume: 47 Issue: 52 Pages: 10187-10191 Published: 2008
We have developed a novel, practical, and enantio- and diastereoselective domino reaction for the
synthesis of functionalized THOs by using a simple amine catalyst. The results disclosed herein demonstrate the ability to control the regio- and stereochemistry of the reaction for the synthesis of THOs from acyclic substrates. We anticipate that a-aminoxylation directed domino reactions will have great potential in the field of organocatalysis. The reaction, which is easy to perform, proceeds cleanly with complete stereocontrol and does not require a change in the reaction conditions or adding reagents. This discovery is likely to be used in synthetic applications, especially since the a-aminoxylation reaction can be combined with existing domino methods.
Address (URL): http://dx.doi.org/10.1002/anie.200803731