Publication Details (including relevant citation information):
Source: Journal of the American Chemical Society Volume: 131 Issue: 13 Pages: 4562-+ Published: APR 8 2009
A novel, facile, and highly enantioselective Brønsted acid-catalyzed α-hydroxylation of β-dicarbonyl compounds with up to 99:1 er using nitroso compounds as the oxygen source has been developed. The results disclosed herein considerably extend the substrate scope for the α-aminoxylation, allowing expeditious, straightforward, and efficient access to valuable α-hydroxy-β-dicarbonyl compounds with the highest levels of enantiocontrol.
Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja8088907