Min Lu - Chiral Brønsted Acid-Catalyzed Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds

Version 1

      Publication Details (including relevant citation   information):

      Source: Journal of the American Chemical Society Volume: 131   Issue: 13 Pages: 4562-+ Published: APR 8 2009

      DOI: 10.1021/ja8088907

      Abstract:

      A novel, facile, and highly enantioselective Brønsted   acid-catalyzed α-hydroxylation of β-dicarbonyl compounds with up   to 99:1 er using nitroso compounds as the oxygen source has been   developed. The results disclosed herein considerably extend the   substrate scope for the α-aminoxylation, allowing expeditious,   straightforward, and efficient access to valuable   α-hydroxy-β-dicarbonyl compounds with the highest levels of   enantiocontrol.

      Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja8088907