Sivaramapanicker Sreejith -  A Near-Infrared Squaraine Dye as a Latent Ratiometric Fluorophore for the Detection of Aminothiol Content in Blood Plasma

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  Publication Details (including relevant citation   information):

  Sivaramapanicker Sreejith, Kizhumuri P. Divya, Ayyappanpillai   Ajayaghosh

  Angewandte Chemie-International Edition,   2008, 47, 7883-7887




  A nucleophilic thiol attack on a weakly fluorescent near-infrared   (NIR)  squaraine dye results in a conjugation break to form   an adduct that  absorbs in the UV/Vis region and is highly   fluorescent. This fluorophore  allows the selective   detection of thiols either by colorimetry or  fluorescence   (see picture). The probe is suitable for the detection and    estimation of the total aminothiol content in human blood plasma.

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