Heidi Ferguson - Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer.

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      Publication Details (including relevant citation   information):

      Bioconjugate chemistry, 2010, 21(4) p.   764-73


      PEGylated dendrimers are attractive for biological applications   due to  their tunable pharmacokinetics and ability to carry   multiple copies of  bioactive molecules. The rapid and   efficient synthesis of a robust and  biodegradable PEGylated   dendrimer based on a polyester-polyamide hybrid  core is   described. The architecture is designed to avoid   destructive  side reactions during dendrimer preparation   while maintaining  biodegradability. Therefore, a dendrimer   functionalized with doxorubicin  (Dox) was prepared from   commercial starting materials in nine,  high-yielding linear   steps. Both the dendrimer and Doxil were evaluated  in   parallel using equimolar dosage in the treatment of C26 murine   colon  carcinoma, leading to statistically equivalent   results with most mice  tumor-free at the end of the 60 day   experiment. The attractive features  of this dendritic drug   carrier are its simple synthesis,  biodegradability, and   versatility for application to a variety of drug  payloads   with high drug loadings.

      Address (URL): http://http://pubs.acs.org/doi/abs/10.1021/bc900553n?prevSearch=%255Bauthor%253A %2BKieler%255D%2BNOT%2B%255Batype%253A%2Bad%255D%2BNOT%2B%255Batype%253A%2Bacs-t oc%255D&searchHistoryKey=