Wei Zhang - Recent advances in structure-based virtual screening of G-protein coupled receptors

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      Publication Details (including relevant citation   information):

      AAPS J. 2009 Mar;11(1):178-85. Epub   2009 Mar 17.


           In addition to the rhodopsin crystal   structure, high-resolution crystal structures of ligand-mediated   G-protein-coupled receptors (GPCRs) have recently become   available, and these have become attractive templates for   developing homology models of several GPCRs of therapeutic   interest. These crystal structures and the homology models   derived from them have provided significant insights into   ligand-receptor interactions. Moreover, several studies have   demonstrated that the structural models are indeed suitable for   virtual screening of compound databases to identify new ligands   for various GPCRs. Recent examples of such virtual screening   against GPCRs are discussed in this review.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/19291412