Kelly Stewart - Cell-penetrating peptides as delivery vehicles for biology and medicine.

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      Publication Details (including relevant citation   information):

     

        Stewart KM,     Horton KL, Kelley SO. Org Biomol Chem. 2008 Jul     7;6(13):2242-55.  2008  

     

     

      Abstract:

      Cell-penetrating peptides (CPPs) have found numerous applications   in  biology and medicine since the first synthetic   cell-permeable sequence  was identified two decades ago.   Numerous types of drugs have been  transported into cells   using CPPs, including small-molecule  pharmaceuticals,   therapeutic proteins, and antisense oligonucleotides.    Improved agents for medical imaging have been generated by   conjugation  with CPPs, with the appended peptides promoting   cellular uptake and in  some cases, cell-type specificity.   Organelle-specific CPPs have also  been generated, providing   a means to target specific subcellular sites.  This review   highlights achievements in this area and illustrates the    numerous examples where peptide chemistry was exploited as a   means to  provide new tools for biology and medicine.

      Address (URL): http://pubs.rsc.org/en/Content/ArticleLanding/2008/OB/b719950c