Byron Brehm-Stecher - Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone.

Document created by Byron Brehm-Stecher on Aug 22, 2014
Version 1Show Document
  • View in full screen mode

  Publication Details (including relevant citation   information):

  Antimicrob Agents   Chemother. 2003 Oct;47(10):3357-60.


  The sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone   were investigated for their abilities to enhance bacterial   permeability and susceptibility to exogenous antimicrobial   compounds. Initially, it was observed by flow cytometry that   these sesquiterpenoids promoted the intracellular accumulation of   the membrane-impermeant nucleic acid stain ethidium bromide by   live cells of Lactobacillus fermentum, suggesting that enhanced   permeability resulted from disruption of the cytoplasmic   membrane. The ability of these sesquiterpenoids to increase   bacterial susceptibility to a number of clinically important   antibiotics was then investigated. In disk diffusion assays,   treatment with low concentrations (0.5 to 2 mM) of nerolidol,   bisabolol, or apritone enhanced the susceptibility of   Staphylococcus aureus to ciprofloxacin, clindamycin,   erythromycin, gentamicin, tetracycline, and vancomycin. Nerolidol   and farnesol also sensitized Escherichia coli to polymyxin B. Our   results indicate the practical utility of sensitizing bacteria to   antimicrobials with sesquiterpenoids that have traditionally been   used as flavorants and aroma compounds in the food and perfume   industries.

  Address (URL):