Kelly Stewart - Mitochondria-penetrating peptides: sequence effects and model cargo transport.

Version 1

      Publication Details (including relevant citation   information):

      Yousif   LF, Stewart KM, Horton KL, Kelley SO Chembiochem. 2009 Aug   17;10(12):2081-8.

     

      Abstract:

      A class of mitochondria-penetrating peptides (MPPs) was studied   in an  effort to optimize their applications in the delivery   of bioactive cargo  to this therapeutically important   organelle. The sequence requirements  for mitochondrial   entry were monitored, and it was discovered that while  an   alternating cationic/hydrophobic residue motif is not required,   the  inclusion of a stretch of adjacent cationic amino acids   can impede  access to the organelle. In addition, a variety   of N- and C-terminal  cargo were tested to determine if   there are limitations to the  lipophilicity, charge, or   polarity of compounds that can be transported  to   mitochondria by MPPs. The results reported demonstrate that   these  peptide sequences are versatile transporters that   will have a range of  biological applications.

      Address (URL): http://onlinelibrary.wiley.com/doi/10.1002/cbic.200900017/abstract;jsessionid=B6 5FD35602A0915D583274F9084F3BDC.d03t03