Antoine Taly - From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

Document created by Antoine Taly on Aug 22, 2014
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  Publication Details (including relevant citation   information):

  Toxins 2011, 3(3), 260-293


  Ligand-gated ion channels (LGIC) play a  central role in   inter-cellular communication. This key function has two    consequences: (i) these receptor channels are major targets for   drug  discovery because of their potential involvement in   numerous human brain  diseases; (ii) they are often found to   be the target of plant and  animal toxins. Together this   makes toxin/receptor interactions important  to drug   discovery projects. Therefore, toxins acting on LGIC are    presented and their current/potential therapeutic uses   highlighted.

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