Idriss Blakey - Characterisation of grafted supports used for solid-phase synthesis.

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      Publication Details (including relevant citation   information):

      Blakey, I.; Day, G.; Girjes, E.; Hunter, D. S.; Rasoul, F.,   Polymer International 2003, 52 (11), 1734-1739.

      DOI: 10.1002/pi.1300


      A series of \"pellicular\" type supports were fabricated by   direct gamma-radiation-mediated graft polymn. of styrene onto   polypropylene, followed by aminomethylation. Raman spectroscopy   was used for measuring the level of penetration of polystyrene   graft into polypropylene, and other structural features such as   d. of graft and depth of functionalisation. The kinetics of the   coupling of fluorenylmethylcarbamate (Fmoc)-labeled amino acids,   to the aminomethylated polystyrene grafts have been measured by   UV absorption followed cleavage of the Fmoc chromophore. The   Raman spectroscopy results showed that for this series of expts.   the calcd. rate coeff. for coupling of Fmoc-labeled amino acids   was primarily dependent on graft thickness, but was also   influenced by the proportion of polystyrene graft to   polypropylene. In general, it was also shown that with increasing   loading capacity of support the calcd. rate coeff. for amino-acid   coupling decreased correspondingly. In addn., a support that had   both a high rate coeff. and a high loading capacity was prepd.   from polypropylene base material with a co-continuous porous   structure (high surface area).

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