Publication Details (including relevant citation information):
C.A. Hawkins and J.W. Dolan, Understanding Split Peaks, LC/GC, 21 (12) 1134-1138, 2003
Peak splitting in a liquid chromatography
(LC) separation results from several
problems. This month’s “LC Troubleshooting”
looks at several possible causes of peak
splitting and presents some guidelines for
isolating the source of peak splitting.
Because some instances of peak splitting
can be indicative of method problems that
should be corrected, it is important to
isolate the problem source carefully, if at all
possible, so you can make method changes
and avoid or delay future problems. In the
end, your method will be more rugged.