Publication Details (including relevant citation information):
Rosen, B.R.; Ney, J. E.; Wolfe, J.P. J. Org. Chem. 2010, 75, 2756.
The development of conditions that allow use of inexpensive aryl chlorides as electrophiles in Pd-catalyzed alkene carboamination and carboetherification reactions is described. A catalyst composed of Pd(OAc)2 and S-Phos minimizes N-arylation of the substrate and prevents formation of mixtures of regioisomeric products. A number of heterocycles, including pyrrolidines, isoxazolidines, tetrahydrofurans, and pyrazolidines, are efficiently generated with this method.
Address (URL): http://pubs.acs.org/doi/abs/10.1021/jo100344k