Idriss Blakey - Self-assembly and encoding of polymer-stabilized gold nanoparticles with surface-enhanced Raman reporter molecules.

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      Publication Details (including relevant citation   information):

      Merican, Z.; Schiller, T. L.; Hawker, C. J.; Fredericks, P. M.;   Blakey, I.,  Langmuir 2007, 23 (21), 10539-10545.

      DOI: 10.1021/la702218b


      Polymer-stabilized gold nanoparticles (AuNPs) were prepared and   encoded  with a range of surface-enhanced Raman reporter   molecules. A range of  as-synthesized polymers produced by   reversible addition fragmentation  chain transfer (RAFT)   polymerization were demonstrated to self-assemble  at the   surface of AuNPs dispersed in water. The method involved   the  coprecipitation of polymer−gold conjugates by the   addition of polymer  dissolved in a water-miscible solvent   to gold AuNPs dispersed in water.  This method represents a   simplification of the preparation of  polymer-stabilized   AuNPs compared with other published methods, in that  the   AuNPs do not need to be first transferred to an organic solvent.   The  process enabled the polymer stabilized AuNPs to be   easily recovered by  filtration or by phase transfer of the   AuNPs to an organic solvent in  which the RAFT polymer was   soluble. The polymer-stabilized AuNPs were  characterized by   a range of methods including UV−visible  spectrophotometry,   transmission electron microscopy, thermogravimetric    analysis, dynamic light scattering, and attenuated total   reflection  Fourier transform infrared spectroscopy.   Furthermore, 1H  pulsed field gradient spin echo   NMR was utilized to characterize the  self-diffusion of the   polymer-stabilized AuNPs. Finally, we then  demonstrated   that these polymer-stabilized AuNPs maintained their    ability to be encoded with surface-enhanced Raman spectroscopy   reporter  molecules.

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