Idriss Blakey - Synthesis and evaluation of partly-fluorinated polyelectrolytes as components in 19F MRI-detectable nanoparticles.

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      Publication Details (including relevant citation   information):

      Nurmi, L.; Peng, H.; Seppälä, J.; Haddleton, D. M.; Blakey, I.;   Whittaker, A. K., Polymer Chemistry 2010, 1, 1039-1047

      DOI: 10.1039/C0PY00035C


      A series of partly fluorinated polyelectrolytes were synthesized   by  transition metal mediated living radical polymerization   and evaluated  for their applicability as corona-forming   components in 19F  MRI-detectable   nanoparticles in aqueous solutions. The polymers were    statistical and block copolymers of trifluoroethyl methacrylate   (TFEMA)  and 2-(dimethylamino)ethyl methacrylate (DMAEMA).   The polymers were  either directly dissolved in water   (statistical copolymers), or  assembled into aqueous   nanoparticles with PTFEMA cores and   P(TFEMA-co-DMAEMA)  coronas (block copolymers). The   polymer composition, polymer charge  density, solution ionic   strength and solution pH were varied. The   19F spin–lattice   (T1) and spin–spin   (T2) relaxation times and   19F image intensities of solutions of   the polymers were measured and related to polymer structure and   aqueous conformation. The 19F NMR   T2 relaxation times were found   to be highly indicative of the 19F   imaging performance. Maintaining sufficient mobility of the   19F nuclei was important for obtaining   images of high intensity. 19F    mobility could be increased by preventing their aggregation in   water by  exploiting electrostatic repulsion between monomer   units.

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