Yang Li - Collagen mimetic peptides: progress towards functional applications

Version 1

      Publication Details (including relevant citation   information):

      S. Michael Yu, Yang Li and Daniel Kim

      Soft Matter, 2011, Advance Article  

        DOI:    10.1039/C1SM05329A 

    Received 24 Feb 2011,   Accepted 04 May 2011
      First published on the web 07 Jun 2011

      Abstract:

      Traditionally, collagen mimetic peptides (CMPs) have been used   for elucidating the structure of the collagen triple helix and   the factors responsible for its stabilization. The wealth of   fundamental knowledge on collagen structure and   cell–extracellular matrix (ECM) interactions accumulated over the   past few decades has led to a recent burst of research exploring   the potential of CMPs to recreate the higher order assembly and   biological function of natural collagens for biomedical   applications. Although a large portion of such research is still   at an early stage, the collagen triple helix has become a   promising structural motif for engineering self-assembled,   hierarchical constructs similar to natural tissue scaffolds which   are expected to exhibit unique or enhanced biological activities.   This paper reviews recent progress in the field of collagen   mimetic peptides that bears both direct and indirect implications   to engineering collagen-like materials for potential biomedical   use. Various CMPs and collagen-like proteins that mimic either   structural or functional characteristics of natural collagens are   discussed with particular emphasis on providing helpful   information to bioengineers and biomaterials scientists   interested in collagen engineering.

      Address (URL): http://pubs.rsc.org/en/Content/ArticleLanding/2011/SM/C1SM05329A