Publication Details (including relevant citation information):
Synlett. 477 (2011). (Invited paper)
The highly enantioselective direct Mannich protocol employing fluoroacetone, p-anisidine, and aldehydes catalyzed by 4-siloxyproline was developed, allowing efficient access for pharmaceutically important fluorinated β-amino ketones. On the basis of DFT calculations and mechanistic probes, the origin of an unusual reversal of regioselectivity was unraveled.