Min Lu - Highly Stereoselective One-Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process

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  Publication Details (including relevant citation   information):

  Angew.   Chem. Int. Ed. 48, 6089   (2009). (highlighted by Synfacts)




            High             five! A novel, facile, and highly             stereoselective synthesis of the title compounds has             been developed with the control of five stereogenic             centers through an organocatalytic asymmetric one-pot             tandem process involving a diastereoselective             intramolecular nitrone [3+2] cycloaddition (see             scheme).            


  Address (URL): http://onlinelibrary.wiley.com/doi/10.1002/anie.200901249/abstract