Min Lu - (1) Chiral Brønsted Acid-Catalyzed Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds

Version 1

      Publication Details (including relevant citation   information):

      J. Am.   Chem. Soc.131, 4562   (2009). (highlighted by Synfacts)

      Abstract:

     

     
       
         
           

              A novel, facile, and highly enantioselective Brønsted           acid-catalyzed α-hydroxylation of β-dicarbonyl compounds           with up to 99:1 er using nitroso compounds as the oxygen           source has been developed. The results disclosed herein           considerably extend the substrate scope for the           α-aminoxylation, allowing expeditious, straightforward,           and efficient access to valuable α-hydroxy-β-dicarbonyl           compounds with the highest levels of enantiocontrol.          

           
         
       
     

      Address (URL): http://pubs.acs.org/doi/abs/10.1021%2Fja8088907