Kelly Stewart - Mitochondria-penetrating peptides

Version 1

      Publication Details (including relevant citation   information):

      K.L.Horton*,   K.M. Stewart*,   S.B. Fonseca, Q. Guo, and S.O. Kelley,Chem.Biol.  2008 15, 375.   *co-authors

      Abstract:

      Mitochondria are important targets for cancer chemotherapy and   other disease treatments. Gaining access to this organelle can be   difficult, as the inner membrane is a barrier limiting diffusive   transport. A mitochondrial molecular carrier would be a boon to   the development of organelle-specific therapeutics. Here, we   report a significant advance in the development of mitochondrial   transporters—synthetic cell-permeable peptides that are able to   enter mitochondria. Efficient uptake of these   mitochondria-penetrating peptides (MPPs) is observed in a variety   of cell types, and organellar specificity is attained with   sequences that possess specific chemical properties. The MPPs   identified are cationic, but also lipophilic; this combination of   characteristics facilitates permeation of the hydrophobic   mitochondrial membrane. The examination of a panel of MPPs   illustrates that mitochondrial localization can be rationally   controlled and finely tuned by altering lipophilicity and charge.

      Address (URL): http://www.cell.com/chemistry-biology/abstract/S1074-5521%2808%2900126-9