Adrian Amador - Fluorescence Turn On by Cholate Aggregates

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  Publication Details (including relevant citation   information):

  Anthony Baldridge, Adrian Amador, and Laren M. Tolbert*

  School of Chemistry and Biochemistry, 901 Atlantic Drive, Georgia   Institute of Technology, Atlanta, Georgia 30332-0400, United   States

  Langmuir, 2011,   27 (7), pp 3271–3274

  DOI: 10.1021/la2003244

  Publication Date (Web): March 11, 2011

  Copyright © 2011 American Chemical Society


  Bile salts, including sodium cholate (NaCh), are amphiphilic   molecules with a concave hydrophilic side and a convex   hydrophobic side. By forming aggregates in aqueous solution,   these natural surfactants fulfill vital biological roles in the   solubilization of cholesterol, lipids, and fat-soluble vitamins   and thus are involved in the transport and absorption of   important biological molecules. Following our success with the   encapsulation of fluorescent protein chromophore (FP) analogs by   synthetic hydrophobic and hydrophilic hosts, based upon   substitution patterns, we now report the binding and turn on of   other analogs by bile salt aggregates, observations which may   lead to new tools for studying trafficking in these important   systems.

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