Publication Details (including relevant citation information):
Arnold, K.; Davies, B.; Giles, R. L.; Grosjean, C.; Smith, G. E.; Whiting, A. Adv. Synth. Catal., 2006, 348, 813‐820
Kinetic studies show that the direct formation
of amides from amines and carboxylic acids
without catalyst does occur under relatively low temperature
conditions, but is highly substrate dependent.
Boric and boronic acid-based catalysts improve
the reaction, especially for less reactive acids, and initial
results indicate that bifunctional catalysts show
even greater potential.