Christophe Grosjean - To Catalyze or not to Catalyze? Insight into Direct Amide Bond Formation from Amines and Carboxylic Acids under Thermal and Catalyzed Conditions

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  Publication Details (including relevant citation   information):

  Arnold, K.; Davies, B.; Giles, R. L.; Grosjean, C.; Smith, G. E.;   Whiting, A. Adv. Synth. Catal., 2006,   348, 813‐820


  Kinetic studies show that the direct formation

  of amides from amines and carboxylic acids

  without catalyst does occur under relatively low temperature

  conditions, but is highly substrate dependent.

  Boric and boronic acid-based catalysts improve

  the reaction, especially for less reactive acids, and initial

  results indicate that bifunctional catalysts show

  even greater potential.

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