Govindasamy Mugesh - Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does an Increase in the Reactivity Alter the Regioselectivity?

Version 1

      Publication Details (including relevant citation   information):

      J. Am. Chem. Soc. 2011, 133, ASAP

      Abstract:

      Organoselenium compounds as functional mimics of iodothyronine   deiodinase are described. The naphthyl-based compounds having two   selenol groups are remarkably efficient in the inner-ring   deiodination of thyroxine. The introduction of a basic amino   group in close proximity to one of the selenol moieties enhances   the deiodination. This study suggests that an increase in the   nucleophilic reactivity of the conserved Cys residue at the   active site of deiodinases is very important for effective   deiodination.

      Address (URL): http://dx.doi.org/10.1021/ja201657s